STUDIES
Medical
Recent advances of nanobubble-based systems in cancer therapeutics: A Review
Cancer is defined by uncontrolled cell growth and metastasis, often due to mutations in the p53 tumor suppressor gene, making it a serious and life-threatening disease. While traditional treatments like chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT) show effectiveness, they come with significant side effects, including light sensitivity, immune suppression, and fatigue, highlighting the need for alternative strategies. Nanobubble therapy (NBT) emerges as a promising approach, utilizing plasmonic nanoparticles to kill cancer cells by disrupting their membranes. Unlike chemotherapy, PTT, and PDT, NBT selectively targets cancer cells, resulting in minimal or no side effects. This review discusses the advantages of NBT over traditional treatments and explores the applications of metal-based nanobubble systems in cancer therapy.
Recent advances of nanobubble-based systems in cancer therapeutics: A Review
Cancer is defined by uncontrolled cell growth and metastasis, often due to mutations in the p53 tumor suppressor gene, making it a serious and life-threatening disease. While traditional treatments like chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT) show effectiveness, they come with significant side effects, including light sensitivity, immune suppression, and fatigue, highlighting the need for alternative strategies. Nanobubble therapy (NBT) emerges as a promising approach, utilizing plasmonic nanoparticles to kill cancer cells by disrupting their membranes. Unlike chemotherapy, PTT, and PDT, NBT selectively targets cancer cells, resulting in minimal or no side effects. This review discusses the advantages of NBT over traditional treatments and explores the applications of metal-based nanobubble systems in cancer therapy.
This study examined the effects of oxygen nanobubble water on wound healing in rats, focusing on ischemic (reduced blood flow) wounds. Rats were divided into groups with ischemic and non-ischemic wounds, and wounds were treated with oxygen nanobubble water, purified water, or saline. While there were no significant differences in healing for non-ischemic wounds, oxygen nanobubble water significantly accelerated healing in ischemic wounds, suggesting it effectively promotes recovery in wounds with limited blood flow.
Reducing Tumor Hypoxia via Oral Administration of Oxygen Nanobubbles
This study investigated the use of orally administered oxygen nanobubbles to reduce tumor hypoxia, a key obstacle in cancer treatment. In a mouse model of human pancreatic cancer, a single dose of oxygen nanobubbles significantly reduced hypoxia-inducible factor-1α (HIF1α) expression by 75% at the transcriptional level and 25% at the protein level, unlike oxygen-saturated water and argon nanobubbles, which had no effect. Oxygen nanobubbles also lowered VEGF levels and increased ARD1A, suggesting enhanced tumor response potential for therapies such as radiation and drugs. This highlights oxygen nanobubbles as a promising method for reducing tumor hypoxia.
A novel nanotechnology-based topical formulation has shown promise in the treatment of diabetic peripheral neuropathy (DPN), aiming to alleviate pain, restore sensitivity, and improve overall function. This advanced topical treatment uses nanotechnology to enhance the delivery and efficacy of active ingredients, targeting nerve damage more effectively. By penetrating deeper skin layers, the formulation aids in reducing neuropathic pain, enhancing nerve sensitivity, and promoting functional recovery in affected areas. This approach represents a potential breakthrough for DPN
Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery
Each year, up to $15 billion of U.S. healthcare costs are spent on treating chronic wounds, often linked to impaired tissue oxygenation. Various methods, including Hyperbaric Oxygen Therapy (HBOT) and Topical Oxygen Therapy (TOT), are used to improve tissue oxygen levels, though their effectiveness remains under investigation. Micro/nanobubbles (MNBs), ranging from 100 μm to under 1 μm in size and stable for extended periods, present a novel approach for oxygen delivery in wound care. This article systematically reviews literature on TOT and MNBs for wound oxygenation using the MEDLINE database, yielding 87 articles (12 on MNBs and 75 on TOT), with 52 meeting the inclusion criteria (12 MNB and 40 TOT studies). Additionally, we evaluate the efficacy of our MNB technology, advocating for its potential as a therapeutic agent in wound healing.
This study explores the use of nanobubble technology to enhance the antibacterial effectiveness of chloroxylenol-based antiseptic (Dettol) against Staphylococcus aureus infections. By creating a nanobubble-based formulation (NB-D) through controlled mixing, researchers achieved a highly stable solution with improved antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus. NB-D significantly reduced the vitality of both bacterial strains in various assays and showed strong biocompatibility, with no cytotoxic effects on human keratinocytes (HaCaT) or hemocytes. The findings suggest that nanobubble technology could effectively boost the performance of antiseptics and disinfectants, offering a promising method to combat infectious pathogens.